Serum levels of 17-hydroxypregnenolone, dehydroepiandrosterone, 17-hydroxyprogesterone, and androstenedione were measured during the postnatal development of rats 1-14 weeks of age. A significant decrease in the serum levels of these steroids with...
In our previous study, we have investigated the serum levels of dehydroepiandrosterone (DHEA) in type 11 collagen (CII)-induced arthritis (CIA) mice. During the study, we found that in normal control mice, serum levels of DHEA in the latter half o...
Y Kawamura-Konishi T Aoki N Satoh M Katagiri H Suzuki
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC 31(1-3) 9-17 2004年10月 [査読有り]
Catalytic antibody 2B generated by immunization with N-methyl mesoporphyrin as hapten catalyzes the insertion of a cupric ion into mesoporphyrin. To identify amino acid residues essential for the catalytic activity, we studied effects of various a...
T Niwa A Kageyama K Kishimoto Y Yabusaki F Ishibashi M Katagiri
DRUG METABOLISM AND DISPOSITION 30(8) 931-936 2002年8月 [査読有り]
The amino acid residues affecting the substrate specificity of human cytochrome P450 CYP2C9 and CYP2C19 for their metabolic activities were investigated using chimeras and mutant enzymes, which were constructed by replacing the corresponding resid...
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